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Abstract
Engineered monocytes and macrophages may enhance therapeutic effectiveness through a coordinated four-layer system.
- Target recognition alone is not sufficient for sustained function of engineered immune cells after entering tissues.
- Recent advancements include myeloid-adapted receptors and in vivo mRNA delivery to improve tissue tracking and cellular function.
- Engineered therapies are structured around sensing, signal integration, actuation, and delivery to optimize their pharmacological action.
- Coordination among these layers is associated with improved exposure and durability of therapeutic effects in various settings.
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