mRNA Nanoparticle Vaccine Targeting Bacterial Attachment Protein Protects Mice from Repeat Urinary Tract Infections

A lipid nanoparticle mRNA vaccine candidate, FimH_DG-Ferritin, has been developed to target uropathogenic E. coli.

• Frequent, recurring urinary tract infections (rUTIs) present significant health and economic challenges.
• Uropathogenic E. coli (UPEC), particularly those expressing the FimH virulence factor, are the primary cause of most UTIs.
• The FimH virulence factor is responsible for mediating bladder colonization by UPEC.
• The new vaccine candidate aims to provide an effective immunization strategy against UPEC.

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