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Characterisation and analysis of mRNA critical quality attributes using liquid chromatography based methods
Analysis of key quality features of mRNA using liquid chromatography methods
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Abstract
mRNA technology has enabled the rapid development of vaccines and holds potential for various therapeutic applications.
- RNA-based therapeutics could be used for treating infectious diseases, cancer, metabolic disorders, cardiovascular conditions, and autoimmune diseases.
- mRNA vaccines and therapeutics function by translating introduced mRNA into the desired protein.
- Analytical methods are necessary to monitor critical quality attributes (CQAs) of mRNA drug substances and products.
- mRNA's polar nature and single-stranded structure may lead to sample heterogeneity, complicating analysis and characterization.
- Recent developments in analytical techniques include high performance liquid chromatography combined with UV detection and mass spectrometry to assess mRNA quality.
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