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Abstract
Male infertility affects 10%-20% of the population globally, with about half of the cases linked to male factors.
- A protocol for delivering mRNA-encapsulated lipid nanoparticles into mouse testis is presented.
- The method involves preparation of mRNA-LNPs, delivery to the rete testis, and evaluation of transfection success.
- Initial findings suggest the system may be relatively safe and efficient for testis transfection.
- This approach could offer a potential therapeutic strategy for individuals experiencing spermatogenic failure.
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