Russian journal of bioorganic chemistry

How mRNA Vaccines Are Made and Delivered

Updated

Abstract

mRNA-based vaccines offer significant advantages over traditional vaccines.

  • mRNA vaccines do not carry the risk of infection since they encode only the target antigen.
  • The genetic information from mRNA is expressed in the cytosol, reducing the likelihood of integration into the host's genome.
  • These vaccines can trigger specific immune responses without provoking an antivector immune response.
  • The platform allows for easy replacement of target genes, potentially speeding up vaccine development during epidemics.
  • The review covers various aspects of mRNA vaccine technology, including stability, modifications, purification, and delivery methods.

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