Nature reviews. Drug discoveryJan 13, 2018

mRNA vaccines: a new stage in vaccine development

mRNA Technology Weekly Brief ↗PubMed ↗DOI ↗

Updated Apr 2, 2026

Abstract

Multiple mRNA vaccine platforms have demonstrated encouraging results in both animal models and humans.

mRNA vaccines offer high potency and rapid development compared to traditional vaccines.
Recent technological advances have improved the stability and delivery efficiency of mRNA.
Applications of mRNA vaccines are being explored for infectious diseases and various cancers.
Future challenges and directions for widespread therapeutic use of mRNA vaccines are discussed.

Simplified

mRNA vaccines represent a promising alternative to conventional vaccine approaches because of their high potency, capacity for rapid development and potential for low-cost manufacture and safe administration. However, their application has until recently been restricted by the instability and inefficient in vivo delivery of mRNA. Recent technological advances have now largely overcome these issues, and multiple mRNA vaccine platforms against infectious diseases and several types of cancer have demonstrated encouraging results in both animal models and humans. This Review provides a detailed overview of mRNA vaccines and considers future directions and challenges in advancing this promising vaccine platform to widespread therapeutic use.

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mRNA vaccines: a new stage in vaccine development

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