mTOR Signaling Pathway’s Role in Antiphospholipid Syndrome and Possible Treatment Targets

mTOR signaling is proposed as a mediator linking inflammation, coagulation, immune dysfunction, thrombosis, and obstetric APS in antiphospholipid syndrome.

This review discusses prior studies connecting mTOR with pro-inflammatory and pro-coagulant processes and frames mTOR activation as a potential pathogenic pathway and therapeutic target in APS.

The abstract presents a mechanistic therapeutic hypothesis rather than new clinical outcome data, and it explicitly notes that APS pathogenesis still needs further exploration.