Targeting mTOR signaling by polyphenols: A new therapeutic target for ageing

Jul 26, 2016Ageing research reviews

Polyphenols may affect mTOR signaling as a new treatment approach for aging

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Abstract

Polyphenolic compounds may inhibit mTOR signaling pathways associated with aging.

Molecular and cellular pathways involved in cellular senescence are key targets for improving health span.
Polyphenols could delay age-related degeneration by affecting mTOR and related pathways.
Inhibition of mTOR signaling may provide new therapeutic strategies for promoting longevity.

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Current ageing research is aimed not only at the promotion of longevity, but also at improving ‎health span‎ through the‎ discovery and development‎ of new therapeutic strategies‎‏‎ by investigating ‎molecular and ‎cellular ‎pathways involved in cellular senescence.‎ Understanding the mechanism of action ‎of ‎polyphenolic compounds targeting mTOR (mechanistic target of rapamycin) and related pathways opens up new directions ‎‎to revolutionize ways to slow down the ‎onset and development of age-dependent degeneration. Herein, we will ‎discuss the mechanisms by which polyphenols can delay the‎ molecular ‎pathogenesis of ageing via manipulation or more specifically inhibition of mTOR-signaling pathways. We will also discuss the implications of polyphenols in targeting mTOR and its related ‎pathways‎‎ on ‎health life span extension and longevity.‎.

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Targeting mTOR signaling by polyphenols: A new therapeutic target for ageing

Abstract

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