Ageing research reviewsJul 26, 2016

Polyphenols may affect mTOR signaling as a new treatment approach for aging

Longevity & Aging Weekly Brief ↗PubMed ↗DOI ↗

Updated Feb 4, 2026

Abstract

Polyphenolic compounds may inhibit mTOR signaling pathways associated with aging.

Molecular and cellular pathways involved in cellular senescence are key targets for improving health span.
Polyphenols could delay age-related degeneration by affecting mTOR and related pathways.
Inhibition of mTOR signaling may provide new therapeutic strategies for promoting longevity.

Simplified

Current ageing research is aimed not only at the promotion of longevity, but also at improving ‎health span‎ through the‎ discovery and development‎ of new therapeutic strategies‎‏‎ by investigating ‎molecular and ‎cellular ‎pathways involved in cellular senescence.‎ Understanding the mechanism of action ‎of ‎polyphenolic compounds targeting mTOR (mechanistic target of rapamycin) and related pathways opens up new directions ‎‎to revolutionize ways to slow down the ‎onset and development of age-dependent degeneration. Herein, we will ‎discuss the mechanisms by which polyphenols can delay the‎ molecular ‎pathogenesis of ageing via manipulation or more specifically inhibition of mTOR-signaling pathways. We will also discuss the implications of polyphenols in targeting mTOR and its related ‎pathways‎‎ on ‎health life span extension and longevity.‎.

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Polyphenols may affect mTOR signaling as a new treatment approach for aging

Abstract

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