The role of mTOR signaling in regulating the quality of mammalian oocytes

Apr 8, 2026Journal of assisted reproduction and genetics

How mTOR signaling affects the health of mammalian egg cells

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Longevity & Aging on OpenScience ↗PubMed ↗DOI ↗

Abstract

Precise control of mTOR activity is essential for maintaining oocyte developmental potential.

mTOR signaling regulates vital cellular processes, including metabolism, protein synthesis, and autophagy.
Dysregulated mTOR activity is linked to impaired oocyte maturation and reduced fertility.
Current knowledge indicates that mTOR plays a significant role in maintaining oocyte quality in mammals.
Understanding mTOR-related mechanisms may reveal new therapeutic strategies to enhance oocyte quality.

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BACKGROUND: mTOR (mammalian target of rapamycin) is a central sensor of cellular nutrient and energy status. It regulates key biological processes, including metabolism, protein synthesis, and autophagy. Increasing evidence shows that mTOR signaling plays an important role in maintaining oocyte quality.

OBJECTIVE: This review aims to provide a systematic overview of how mTOR signaling regulates oocyte quality in mammals.

CONTENT: We summarize current knowledge on the role of mTOR in key cellular processes related to oocyte competence. These processes include metabolic regulation, translational control, autophagy, and mitochondrial function. We also discuss evidence from experimental and clinical studies. These studies link dysregulated mTOR activity to impaired oocyte maturation and reduced fertility.

KEY FINDINGS: Current evidence shows that precise control of mTOR activity is essential for maintaining oocyte developmental potential. In contrast, the dysregulation of mTOR impairs oocyte quality and negatively affects reproductive outcomes.

CONCLUSION: A better understanding of mTOR-related regulatory mechanisms may help identify new therapeutic strategies. These strategies may improve oocyte quality and female fertility.

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The role of mTOR signaling in regulating the quality of mammalian oocytes

Abstract

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