MUC15 acts as a tumor suppressor gene which correlates with prognosis and immune infiltration in esophageal squamous cell carcinoma

Apr 14, 2025International journal of medical sciences

MUC15 may suppress tumors and relates to outlook and immune response in esophageal squamous cell cancer

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Abstract

MUC15 may serve as a tumor suppressor gene for esophageal squamous cell carcinoma (ESCC).

The study utilized RNA sequencing data and clinical data from TCGA and GEO databases to identify potential biomarkers for ESCC.
Weighted co-expression network analysis highlighted candidate biomarkers, with MUC15 being selected for further evaluation.
ROC curve analysis was conducted to assess the sensitivity and specificity of the identified biomarkers.
CIBERSORT was employed to estimate immune cell type abundances based on gene expression profiles.
Both univariate and multiple Cox regression analyses were performed to identify prognostic factors related to ESCC.

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Esophageal squamous cell carcinoma (ESCC), as a common malignant tumor of the digestive system, has been a challenge in improving and prolonging the postoperative survival of patients. This study aims to identify novel biomarkers that can guide the clinical diagnosis and treatment by using bioinformatics methods. The RNA-seq data and corresponding clinical data of ESCC were downloaded from the TCGA and GEO database. Weighted co-expression network analysis (WGCNA) was used to identify candidate biomarkers. The LASSO analysis was performed to classify the biomarkers. ROC curve and AUC were used to evaluate the sensitivity and specificity of biomarkers. CIBERSORT was applied to estimate the relative abundances of immune cell types through gene expression profiling. Univariate and multiple Cox regression were performed to screen out prognostic factors. MUC15, which abnormally expressed in different physiological processes and participates in inhibiting or promoting function in different types of tumors, was selected of candidate biomarker. Finally, we validated the expression of MUC15 in ESCC tissues and its inhibitory effect on cell function throughandexperiments. In conclusion, we identified MUC15 could serve as a tumor suppressor gene and may become a promising candidate for individualized clinical diagnosis and treatment of ESCC. in vitro in vivo

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MUC15 acts as a tumor suppressor gene which correlates with prognosis and immune infiltration in esophageal squamous cell carcinoma

Abstract

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