Mulberroside A repairs high fructose diet‐induced damage of intestinal epithelial and blood–brain barriers in mice: A potential for preventing hippocampal neuroinflammatory injury

Mulberroside A (20 and 40 mg/kg) prevented high fructose diet-induced neuroinflammatory injury in mice over 8 weeks.

• High fructose diets are associated with gut dysbiosis, leading to reduced fecal short-chain fatty acids and intestinal epithelial barrier damage.
• Mulberroside A reshaped gut microbiota, increased fecal and serum short-chain fatty acids, and reactivated the colonic NLRP6 inflammasome.
• Treatment with mulberroside A reduced serum endotoxin levels and inhibited oxidative stress in the colon of high fructose diet-fed mice.
• Neuroinflammation and decreased neurogenesis in the hippocampus were inhibited by mulberroside A in the context of high fructose diet.
• Mulberroside A helped maintain astrocyte morphology and up-regulated tight junction proteins, contributing to the repair of blood-brain barrier structure defects.

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