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A Multi-omic Association Study of Trimethylamine N-Oxide
A study linking trimethylamine N-oxide to multiple biological factors
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Abstract
Kidney markers are strongly associated with levels of plasma TMAO.
- TMAO is linked to the development of atherosclerosis and cardiovascular disease.
- Blood markers, metabolites, proteins, and gut microbiota patterns are significantly associated with TMAO levels.
- CVD-related proteins show a positive correlation with TMAO.
- Metabolites produced by gut microbiota are strongly correlated with TMAO, with correlation strength varying by kidney function.
- Diet-related patterns in the microbiome are correlated with TMAO levels.
- The accumulation of TMAO and its role in promoting atherosclerosis involves complex interactions between diet, microbiome, and other systemic factors.
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