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Multi-omics analysis reveals novel causal pathways in psoriasis pathogenesis
Combined molecular analyses reveal new possible causes of psoriasis
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Abstract
Significant causal associations were identified between DNA methylation, gene expression, protein levels, and psoriasis risk.
- Two pathways involving the long non-coding RNA RP11-977G19.11 and apolipoprotein F (APOF) were discovered.
- Methylation at sites cg26804944 and cg02705573 was negatively associated with RP11-977G19.11 expression.
- Reduced RP11-977G19.11 expression was linked to increased APOF levels, which were positively associated with a higher risk of psoriasis.
- Methylation at sites cg00172967, cg00294382, and cg24773560 was positively associated with RP11-977G19.11 expression.
- Elevated RP11-977G19.11 expression was associated with decreased APOF levels, which may reduce the risk of psoriasis.
- Colocalization analysis highlighted APOF as a key protein in psoriasis pathogenesis.
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Key numbers
0.753
Causal Association Odds Ratio (cg26804944)
Methylation at cg26804944 associated with reduced expression of RP11-977G19.11
1.029
Causal Association Odds Ratio (APOF)
APOF levels positively associated with psoriasis risk
5,459 cases and 324,074 controls
Psoriasis Cohort Size
Cohort data from EMBL-EBI for psoriasis analysis