Multiple types of cell death contribute to immune damage in RSV infection

Respiratory syncytial virus (RSV) activates multiple regulated cell death programs, including apoptosis and necroptosis.

• RSV interacts with immune responses through a multimodal cell death network that includes various regulated cell death programs.
• Central mediators like caspase-8, RIPK3, and NLRP3 play critical roles in coordinating these death programs and enhancing inflammation.
• The integrated cell death system may influence the balance between eliminating the virus and causing tissue damage.
• Understanding the multimodal cell death network could provide insights into the mechanisms of RSV-related immune dysfunction.
• Potential therapeutic strategies may focus on modulating this network to restore immune balance while maintaining antiviral responses.

Simplified