Full text is available at the source.
Multimodal clocks of human aging
Using multiple biological measures to track human aging
AI simplified
Abstract
Aging was assessed using data from 2,019 Chinese individuals aged 18-91 years.
- A three-tiered aging framework was developed, including a core capacity clock, a multimodal clock, and organ-associated aging clocks.
- Plasma protein clocks capture chronological age and may serve as effective measures of overall physiological capacity.
- The study identified that the accumulation of coagulation factors increases with age and may drive multi-organ aging and systemic inflammation.
- This framework connects molecular changes with functional decline and may help in identifying new biomarkers for assessing aging.
AI simplified