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Abstract
Aging was assessed using data from 2,019 Chinese individuals aged 18-91 years.
- A three-tiered aging framework was developed, including a core capacity clock, a multimodal clock, and organ-associated aging clocks.
- Plasma protein clocks capture chronological age and may serve as effective measures of overall physiological capacity.
- The study identified that the accumulation of coagulation factors increases with age and may drive multi-organ aging and systemic inflammation.
- This framework connects molecular changes with functional decline and may help in identifying new biomarkers for assessing aging.
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