Cell reports. MedicineSep 25, 2025

Detailed molecular profile of the person with the longest lifespan

Longevity & Aging Weekly Brief ↗PubMed ↗DOI ↗

Updated Jun 27, 2026

Abstract

Essence

A multiomics profile of the world's oldest living person suggests distinct markers of extreme age and unusually healthy aging.

Evidence

High-throughput single-person multiomics study compared genome, transcriptome, metabolome, proteome, microbiome, and epigenome results with larger matched cohorts.

Caveat

The central evidence comes from one extreme-lifespan individual, and the abstract says generalization requires larger cohorts and longitudinal prospective studies.

Simplified

Extreme human lifespan, exemplified by supercentenarians, presents a paradox in understanding aging: despite advanced age, they maintain relatively good health. To investigate this duality, we have performed a high-throughput multiomics study of the world's oldest living person, interrogating her genome, transcriptome, metabolome, proteome, microbiome, and epigenome, comparing the results with larger matched cohorts. The emerging picture highlights different pathways attributed to each process: the record-breaking advanced age is manifested by telomere attrition, abnormal B cell population, and clonal hematopoiesis, whereas absence of typical age-associated diseases is associated with rare European-population genetic variants, low inflammation levels, a rejuvenated bacteriome, and a younger epigenome. These findings provide a fresh look at human aging biology, suggesting biomarkers for healthy aging, and potential strategies to increase life expectancy. The extrapolation of our results to the general population will require larger cohorts and longitudinal prospective studies to design potential anti-aging interventions.