NPJ vaccines

Health outcomes in multiple organs after Pfizer COVID-19 vaccination compared to COVID-19 infection in 30 million people

Updated

Abstract

SARS-CoV-2 infection is associated with 3- to 5-fold increases in cardiovascular events during the acute phase.

  • Myocarditis risk is higher for males (RR 4.44) and females (RR 5.59) following SARS-CoV-2 infection.
  • All-cause mortality risk increases for males (RR 4.53) during the acute phase of infection.
  • BNT162b2 vaccination results in 65-76% reductions in major adverse cardiovascular events within the first three months.
  • Post-infection vaccination (hybrid immunity) leads to an additional 36-38% reduction in major adverse cardiovascular events.
  • Completing the two-dose vaccination series reduces mortality by 77% and myocarditis by 62% compared to single dosing.
  • SARS-CoV-2 infection presents a greater and more sustained cardiovascular risk than BNT162b2 vaccination across all groups.

Simplified

Full Text

Full text is available at the source.

Funding

Competing interests

Competing interests: S.J.T. was an investigator in the phase 3 trial of the BNT162b2 COVID-19 vaccine and has participated on data safety monitoring boards, independent data monitoring committees, and in consultative and advisory capacities for several industry sponsors of COVID-19 vaccines. He has been compensated for his time. The remaining authors (E.A.T., D.B., M.H.H., and H.A.) declare no competing interests.
PubMed

What Lands in Your Inbox Each Week:

  • 📚7 fresh studies
  • 📝plain-language summaries
  • direct links to original studies
  • 🏅top journal indicators
  • 📅weekly delivery
  • 🧘‍♂️always free