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Abstract
Detailed characterization of suspended mRNA-lipid nanoparticles (LNPs) reveals their size, mass, and payload characteristics.
- The method enables simultaneous measurement of size, mass, refractive index, and nucleic acid payload of individual LNPs.
- Accuracy and precision were validated using nanosized beads.
- Different solvent pH conditions were investigated for their effects on the size, payload, and water content of LNPs.
- The approach combines conventional microscopy with advanced confinement techniques, potentially enhancing nanoparticle analysis.
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