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Multiscale Time-resolved Analysis Reveals Remaining Behavioral Rhythms in Mice Without Canonical Circadian Clocks
Detailed Timing Analysis Shows Ongoing Daily Behavior Rhythms in Mice Without Normal Body Clocks
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Abstract
Four rhythmic components with periods of ∼17 h, ∼8 h, ∼4 h, and ∼20 min were identified in mice lacking the canonical circadian clock.
- Circadian rhythms are internal processes repeating approximately every 24 hours, primarily synchronized to environmental light-dark cycles.
- , which are shorter than circadian rhythms, are less understood in terms of their biological mechanisms and significance.
- In the absence of the canonical circadian clock, distinct rhythmic components were observed, including periods of approximately 17 hours, 8 hours, 4 hours, and 20 minutes.
- The presence of the ∼17-h rhythm correlated with a low amplitude of the ∼8-h rhythm, occurring in a periodic manner every 2-3 weeks.
- The ∼4-h and ∼20-min rhythms were found to be harmonics of the ∼8-h rhythm, indicating a structured relationship among these oscillators.
- Strong was observed from slower rhythms (∼17, ∼8, and ∼4 h) to faster rhythms (∼20 min), while coupling in the reverse direction was weak.
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Key numbers
17 h, 8 h, 4 h, 20 min
Oscillation Periods
Four distinct rhythmic components were observed.
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Coupling Strength
Mean coupling strength between oscillations when above the surrogate threshold.