Gut bacteria Muribaculaceae control a bile acid to affect S1PR2 signaling and lessen brain damage after bleeding in the brain

Intestinal flora imbalance after intracerebral hemorrhage is associated with aggravated neuroinflammation and secondary brain injury.

• Muribaculaceae and β-muricholic acid may play regulatory roles in neurological injury following intracerebral hemorrhage.
• The specific molecular mechanism through which these factors improve prognosis remains unclear.
• Sphingosine-1-phosphate receptor 2 (S1PR2) is implicated in the potential neuroprotective effects of these regulatory factors.

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