Communication Between Muscle and Bone Through the Muscle Protein Irisin

Mice treated with a micro-dose of r-Irisin displayed improved cortical bone mass, geometry, and strength.

• Skeletal muscle is recognized as an endocrine organ that produces myokines, including Irisin, in response to physical exercise.
• Irisin has been shown to promote energy expenditure in white adipose tissue.
• The effects of Irisin on skeletal metabolism have been demonstrated in vivo.
• Irisin exhibits an autocrine effect on skeletal muscle.
• In humans, Irisin levels increase with physical activity, confirming its role as a circulating hormone-like myokine.

Simplified