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Trends in the discovery of new drugs for Mycobacterium tuberculosis therapy with a glance at resistance
Trends in discovering new drugs for tuberculosis treatment and drug resistance
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Abstract
In 2015, there were an estimated 10.4 million new tuberculosis (TB) cases worldwide.
- Despite the availability of a four-drug treatment regimen for 40 years, TB remains a significant health issue.
- The rise in multidrug-resistant (MDR-TB), extensively-drug resistant (XDR-TB), and totally drug-resistant (TDR-TB) cases is concerning.
- MDR-TB and XDR-TB are associated with lower cure rates and higher mortality due to treatment challenges.
- Recent developments include new drugs and regimens aimed at treating all forms of TB.
- There is growing scientific interest in host-directed therapies (HDTs) to find new treatments for MDR-TB.
- The review highlights discoveries of new drugs and examines the molecular mechanisms behind drug resistance in Mycobacterium tuberculosis.
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