Muscle cell exosome miR-140-5p influences muscle repair by controlling muscle stem cells

Myogenic exosomes carrying miR-140-5p inhibitors significantly enhance satellite cell proliferation.

• Myogenic exosomes can activate satellite cells, which are crucial for muscle repair.
• Expression of miR-140-5p is significantly reduced during the repair of skeletal muscle injuries in mice.
• The addition of myogenic exosomes leads to an increase in cell cycle progression from G1 to S phase.
• Treatment with myogenic exosomes results in a substantial increase in muscle growth-related gene expression in the gastrocnemius muscle.
• Activation of satellite cells by myogenic exosomes may promote the formation of new skeletal muscle cells.

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