Physical Activity Influences the Gut-Brain Link Through Muscle Signals and Gut Bacteria to Affect Brain Inflammation

Emerging evidence highlights physical activity as a potent modulator of the gut-brain axis in neurodegenerative diseases.

• Neurodegenerative diseases may be influenced by both neural pathology and systemic physiological networks.
• The gut-brain axis is recognized as a significant communication system between the gut and brain.
• Muscle-derived signals, such as myokines, metabolites, and extracellular vesicles, could play a central role in this communication.
• Physical activity is associated with modulation of the gut-brain axis, potentially impacting neurodegenerative disease progression.

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