N-truncated Aβ4–x peptides in sporadic Alzheimer’s disease cases and transgenic Alzheimer mouse models

Amyloid-β staining was primarily found in amyloid plaque cores and in cerebral blood vessels in brains affected by Alzheimer's disease and Down syndrome.

• N-terminally truncated amyloid-β peptides may play a significant role in the aggregation process leading to plaque formation.
• Immunohistochemical analysis revealed that staining for these peptides was concentrated in specific areas associated with amyloid pathology.
• Diffuse amyloid deposits showed little to no reactivity for the newly developed antibodies targeting truncated amyloid-β species.
• No significant staining was detected within neurons, indicating that the amyloid-β peptides are primarily localized outside of neuronal cells.

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