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Abstract
Over 80% of all RNA methylation modifications are attributed to N-methyladenosine (mA).
- More than 160 RNA modifications have been identified, including mG, mA, and mC.
- mA modification is highly dynamic and may influence reproduction and development in organisms.
- Significant advancements in understanding mA modification mechanisms have been achieved through various techniques.
- Single-molecule real-time and nanopore direct RNA sequencing offer new methods to study RNA modifications at the cellular level.
- Challenges remain in creating precise dynamic maps of mA modifications and improving detection specificity.
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