Loss of NAD+ metabolism linked to stopped skin lining growth in Hirschsprung disease

Hirschsprung disease (HSCR) is marked by distal aganglionosis.

• Postoperative complications like dysmotility and enterocolitis may indicate ongoing issues in the bowel.
• The study seeks to clarify the condition of the epithelial tissue in HSCR.
• Metabolic characteristics of the bowel epithelium in HSCR are also investigated.

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