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Abstract
Serpina3n is identified as a key mediator in protecting muscle integrity through NAD+ supplementation.
- Nicotinamide adenine dinucleotide (NAD+) supplementation may trigger the release of Serpina3n from adipose tissue.
- Increased Serpina3n is associated with protection against muscle atrophy in models of aging, disuse, and cancer cachexia.
- Serpina3n helps preserve the protein level of pyruvate carboxylase in muscle, which could enhance energy production and protein synthesis.
- These findings suggest a signaling mechanism that connects metabolic status in fat tissue to muscle preservation.
Simplified
Longevity & Aging