Challenges and considerations for using NAD+ supplements and PARP blockers after spinal cord injury in mice

The effectiveness of poly(ADP-ribose) polymerase (PARP) inhibition and NAD⁺ supplementation in spinal cord injury (SCI) is examined in a narrative review and data-based perspective.

• Current literature on PARP inhibition and NAD⁺ supplementation in SCI is analyzed.
• Both treatment approaches are associated with potential improvements in pathophysiological outcomes.
• Findings are based on studies conducted in mice, indicating a focus on preclinical models.
• The review aims to identify the relative effectiveness of these treatment paradigms.

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