NADH dehydrogenase may help improve metabolic issues related to diet and biological clocks.

Genetic loss of the circadian clock in male mice led to reduced complex I respiration in adipose tissue.

• Circadian clocks help regulate daily biological processes, including metabolism.
• Disruption of these clocks is linked to obesity, metabolic disease, and cancer.
• Reduced complex I respiration was observed in adipocytes from mice lacking the circadian clock and fed a high-fat diet.
• Impairment of PPAR and insulin signaling pathways was associated with this reduced respiration.
• Maintaining complex I function protected against metabolic dysfunction despite weight gain.
• Circadian disruption affects metabolic health by causing dysfunction in mitochondrial complex I.

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