ACS biomaterials science & engineeringJun 1, 2024

Using Nanomaterial-Enhanced Bioinks to Improve 3D Bioprinting for Tissue Repair

Regenerative Health Weekly Brief ↗PubMed ↗DOI ↗

Updated Feb 15, 2026

Abstract

Nanomaterials-based hybrid bioinks have the potential to enhance 3D bioprinting for soft tissues.

3D bioprinting can be used to create tissues or organs, potentially reducing the need for artificial organs.
Formulations of bioink with improved properties are critical for effective bioprinting of soft tissues like kidneys and hearts.
Hybrid bioinks made from natural and synthetic nanomaterials can enhance bioprintability, biocompatibility, and biodegradability.
Various nanomaterials, such as carbon nanotubes and graphene oxides, have been incorporated into bioinks for improved performance.
The review addresses applications, challenges, limitations, ethical considerations, and future perspectives in the field of 3D bioprinting.

Simplified

3D bioprinting is recognized as the ultimate additive biomanufacturing technology in tissue engineering and regeneration, augmented with intelligent bioinks and bioprinters to construct tissues or organs, thereby eliminating the stipulation for artificial organs. For 3D bioprinting of soft tissues, such as kidneys, hearts, and other human body parts, formulations of bioink with enhanced bioinspired rheological and mechanical properties were essential. Nanomaterials-based hybrid bioinks have the potential to overcome the above-mentioned problem and require much attention among researchers. Natural and synthetic nanomaterials such as carbon nanotubes, graphene oxides, titanium oxides, nanosilicates, nanoclay, nanocellulose, etc. and their blended have been used in various 3D bioprinters as bioinks and benefitted enhanced bioprintability, biocompatibility, and biodegradability. A limited number of articles were published, and the above-mentioned requirement pushed us to write this review. We reviewed, explored, and discussed the nanomaterials and nanocomposite-based hybrid bioinks for the 3D bioprinting technology, 3D bioprinters properties, natural, synthetic, and nanomaterial-based hybrid bioinks, including applications with challenges, limitations, ethical considerations, potential solution for future perspective, and technological advancement of efficient and cost-effective 3D bioprinting methods in tissue regeneration and healthcare.

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Using Nanomaterial-Enhanced Bioinks to Improve 3D Bioprinting for Tissue Repair

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