Using a Tiny Enzyme Carrier with Resveratrol to Treat Osteoarthritis by Regulating Cell Signaling and Joint Environment

PMRH nanoparticles effectively scavenge reactive oxygen species (ROS) in the osteoarthritis microenvironment.

• Osteoarthritis is associated with oxidative stress and abnormal activation of the Wnt/β-catenin signaling pathway.
• Resveratrol and platinum nanozymes were loaded onto a metal-organic framework to create a new nanoparticle system.
• The PMRH nanoparticles are designed to inhibit the Wnt/β-catenin signaling pathway and eliminate ROS simultaneously.
• In vitro and in vivo results indicate that PMRH nanoparticles can efficiently reduce ROS levels in osteoarthritis-affected areas.
• The dual-target approach of PMRH nanoparticles suggests potential for improved prevention and treatment of osteoarthritis.

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