Naringin reduces damage to brain cell energy structures and overactive cleanup after stroke by affecting specific protein pathways

Naringin may reduce cerebral ischemia-reperfusion injury by blocking harmful mitophagy induced by peroxynitrite.

• Mitophagy is crucial for preventing damage from cerebral ischemia-reperfusion injury.
• Naringin could prevent harmful mitophagy that is triggered by peroxynitrite.
• Mitochondrial calcium efflux is linked to stabilizing mitochondrial function and activating protective mitophagy.
• The relationship between naringin's effects and mitochondrial calcium is not yet clearly understood.

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