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Nasal Delivery of Phytochemicals Using Nanocarriers: Therapeutic Opportunities and Translational Challenges
Using Tiny Carriers to Deliver Plant-Based Medicines Through the Nose: Treatment Benefits and Challenges
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Abstract
Phytochemical-nanotechnology formulations may enhance nasal drug delivery for improved therapeutic efficacy and brain targeting.
- like curcumin, resveratrol, and quercetin have strong pharmacological properties but are limited by poor solubility and bioavailability.
- Nanotechnology systems, including nanoparticles and liposomes, can improve the stability, absorption, and controlled release of these phytochemicals.
- Challenges such as nasal mucosa irritation and regulatory barriers currently hinder the clinical application of these formulations.
- Encapsulating curcumin in polymeric nanoparticles has improved its solubility and bioavailability in preclinical Alzheimer's models.
- This integration of phytochemicals and nanotechnology may lead to innovative nasal delivery systems for various medical conditions.
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