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Abstract
Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by progressive mitochondrial dysfunction that disrupts hepatocellular metabolism.
- Mitochondrial dysfunction in MASLD leads to impaired metabolism, disrupted redox balance, and compromised communication between cellular compartments.
- Chronic nutrient excess and insulin resistance disturb the spatial organization of liver cells, especially affecting pericentral hepatocytes.
- This disruption results in oxidative stress, poor mitochondrial quality control, and an accumulation of lipids in the liver.
- Mitochondrial injury triggers the release of mitochondrial DNA and other molecules that activate immune cells, increasing inflammation and fibrosis.
- Certain natural compounds may improve mitochondrial function by promoting specific cellular processes related to mitochondrial health and reducing immune activation.
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