Natural Products and LncRNAs in Non‐Small Cell Lung Cancer: Emerging Therapeutic Approaches

Nov 20, 2025The journal of gene medicine

Natural Compounds and Long Noncoding RNAs as New Treatments for Non-Small Cell Lung Cancer

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Abstract

Long non-coding RNAs (lncRNAs) significantly influence the progression of non-small cell lung cancer (NSCLC).

lncRNAs are associated with cell proliferation, cell death regulation, and treatment resistance in NSCLC.
Natural products like curcumin, resveratrol, and epigallocatechin gallate may modulate lncRNA activity and affect cancer progression.
These compounds could inhibit metastasis and reverse chemoresistance by regulating oncogenic lncRNAs.
Natural products may also enhance the expression of tumor-suppressive lncRNAs, aiding in cell cycle control and apoptosis.
The review highlights the potential for natural products to be integrated into therapeutic strategies for NSCLC.

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Non-small cell lung cancer (NSCLC) is considered a major contributor to cancer-related death rates worldwide, chiefly owing to late diagnosis, occurrence of metastasis, and treatment resistance. Growing evidence underscores the impact of long non-coding RNAs (lncRNAs) on NSCLC progression. These lncRNAs have been demonstrated to influence cell proliferation, apoptosis, epithelial-mesenchymal transition (EMT), and drug resistance, contributing to cancer development and therapeutic failure. Concurrently, natural products and nutraceuticals are gaining attention for their anticancer properties, particularly in modulating signaling pathways involved in tumorigenesis and drug resistance. Compounds like curcumin, resveratrol, and epigallocatechin gallate have been shown to regulate oncogenic lncRNAs, inhibiting metastasis and reversing chemoresistance. Additionally, natural products upregulate tumor-suppressive lncRNAs, restoring cell cycle control and apoptosis. This review provides an in-depth analysis of the etiological significance of lncRNAs in NSCLC, with a particular emphasis on their contribution to tumorigenesis, metastasis, and therapeutic resistance. In addition, it explores the potential of natural products to modulate lncRNA expression, highlighting their efficacy in overcoming drug resistance and enhancing the therapeutic response. By elucidating the dynamic molecular cross-talk between lncRNAs and natural products, this review also aims to identify novel therapeutic strategies and potential biomarkers for the diagnosis and treatment of NSCLC.

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Natural Products and LncRNAs in Non‐Small Cell Lung Cancer: Emerging Therapeutic Approaches

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