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NEOage clocks - epigenetic clocks to estimate post-menstrual and postnatal age in preterm infants
Epigenetic clocks to estimate developmental and birth age in premature babies
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Abstract
High correlations (0.93 - 0.94) were observed between predicted and reported ages in a study of 542 very preterm infants.
- Four epigenetic clocks (NEOage Clocks) were developed to predict post-menstrual and postnatal age in preterm infants.
- Buccal cells were collected at NICU discharge to analyze DNA methylation patterns.
- Root mean squared errors ranged from 1.28 to 1.63 weeks, indicating strong predictive accuracy.
- Epigenetic estimators may provide insights into biological maturity for neonates, particularly those born preterm.
- These tools could be associated with the evaluation of neonatal and long-term health outcomes.
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