Neural and Genetic Correlates of Antidepressant Response to Sleep Deprivation

Feb 7, 2007Archives of general psychiatry

Brain activity and gene links to antidepressant effects of sleep deprivation during moral decisions in bipolar depression

AI simplified

Circadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

Twenty inpatients with bipolar depression underwent total sleep deprivation combined with light therapy for 1 week.

Significant interactions were observed between treatment responses and the moral valence of stimuli in specific brain areas, including the anterior cingulate cortex and dorsolateral prefrontal cortex.
Responders to treatment showed changes in brain responses to emotional stimuli that differed from nonresponders.
The genotype of the serotonin transporter promoter was associated with treatment response and influenced baseline brain activity in certain regions.
These findings suggest that individual factors related to major depressive episodes interact to affect brain activity during depressive episodes.

AI simplified

CONTEXT: Total sleep deprivation combined with light therapy causes rapid amelioration of bipolar depression. A polymorphism in the promoter for the serotonin transporter influences both antidepressant response and the structure and function of specific brain areas.

OBJECTIVE: To determine whether antidepressant therapy or the genotype of the serotonin transporter influence the pattern of neural response to a task targeting the depressive biases in information processing (moral valence decision).

DESIGN: Before-and-after trial studying the biologic correlates of response to treatment.

SETTING: University hospital. Patients Twenty inpatients with bipolar depression. Intervention Repeated total sleep deprivation combined with light therapy for 1 week.

MAIN OUTCOME MEASURES: Brain blood oxygen level-dependent functional magnetic resonance imaging using a 3.0-T scanner before and after treatment. Self-ratings and observer ratings of mood (visual analog scale 3 times daily and Hamilton Depression Rating Scale) before and after treatment.

RESULTS: We found significant interactions of treatment (before and after), response to treatment (Hamilton Depression Rating Scale score <8), and moral valence of the stimuli (positive or negative) in the anterior cingulate cortex, dorsolateral prefrontal cortex, insula, and parietal cortex. In these areas, responders changed their blood oxygen level-dependent responses to emotional stimuli in a pattern opposite of that in nonresponders. Genotype of the promoter for the serotonin transporter predicted response to treatment and influenced baseline neural responses in the anterior cingulate cortex and the dorsolateral prefrontal cortex.

CONCLUSION: Multiple factors that affect or are affected at the individual level by major depressive episodes in the course of bipolar disorder significantly interact in influencing brain cortical activity in specific areas.

Full Text

Full text is available at the source.

View full text ↗

Neural and Genetic Correlates of Antidepressant Response to Sleep Deprivation

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief