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Neural regulation of gut inflammation via autonomic nerves: therapeutic implications for inflammatory bowel disease
Nerve control of gut inflammation and its treatment potential for inflammatory bowel disease
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Abstract
Inflammatory bowel disease (IBD) is linked to complex interactions between the immune system and the autonomic nervous system.
- Vagus nerve signaling may regulate intestinal immune responses and influence IBD pathogenesis.
- Psychological stress could alter gut immune function, potentially contributing to treatment-resistant depression.
- Enteric glial activation and changes in gut microbiota metabolites are associated with immune activation during stress.
- Gut microbiota imbalances may play a role in neurodegenerative disorders, affecting brain health through systemic inflammation.
- Emerging strategies in bioelectronic neuromodulation may offer non-drug approaches to restore immune balance in the gut.
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