Possible neurobiological mechanisms underlying faster onset of antidepressant action.

Some antidepressant agents may reduce depressive symptoms more rapidly than others.

• Selective serotonin reuptake inhibitors, venlafaxine, and mirtazapine influence serotonin and norepinephrine levels.
• The review focuses on how quickly these drugs affect neurotransmission compared to traditional antidepressants.
• There is potential for some antidepressants to act faster or have a stronger effect than others.
• Strategies to enhance or speed up the antidepressant response are discussed, with some already tested in patients.

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