Neurocognitive effects of repeated ketamine infusions in comorbid posttraumatic stress disorder and major depressive disorder

Fifteen veterans with comorbid PTSD and major depressive disorder received six infusions of 0.5 mg/kg ketamine over 12 days.

• Repeated ketamine infusions did not significantly worsen cognitive performance.
• Significant improvement in working memory was observed following the infusion series.
• Greater improvements in PTSD and depression symptoms were linked to lower baseline working memory and slower processing speed.
• Faster set shifting at baseline was associated with better treatment outcomes.
• Lower verbal learning scores predicted greater improvement in depression symptoms.

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