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The Crossroads of Neurodegeneration: Exploring the Overlap Between Alzheimer's Disease and Depression
Overlap Between Alzheimer's Disease and Depression in Brain Degeneration
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Abstract
Alzheimer's disease and depression share multiple overlapping features that may complicate diagnosis and treatment.
- Both disorders may involve common biological pathways, including oxidative stress and mitochondrial dysfunction.
- Microglial activation and vascular impairment are implicated in the progression of both Alzheimer's disease and depression.
- Biomarkers such as lipid peroxidation and nucleic acid damage could be indicative of shared pathological processes.
- Telomerase activity and ferroptosis may play roles in neuronal cell death related to both conditions.
- Antidepressants might have the potential to influence the disease trajectory in Alzheimer's patients with depressive symptoms.
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