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Promoting neurogenesis via Wnt/β-catenin signaling pathway accounts for the neurorestorative effects of morroniside against cerebral ischemia injury
Morroniside may help brain repair after stroke by boosting new nerve cell growth through the Wnt/β-catenin pathway
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Abstract
Morroniside significantly promoted neurogenesis for brain recovery 7 days post-ischemia.
- Neurogenesis triggered by ischemia in the adult brain may offer insights into stroke treatment.
- Morroniside, derived from C. officinalis, has shown neuroprotective effects.
- Increased levels of Wnt 3a, β-catenin, and T-cell transcription factor-4 (Tcf-4) were observed.
- Activation of transcription factors Pax6 and neurogenin2 (Ngn2) was linked to morroniside administration.
- The findings suggest that the neurorestorative effects of morroniside may involve the Wnt/β-catenin signaling pathway.
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