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Abstract
Single-cell RNA sequencing has revealed novel disease-associated cell subsets in Alzheimer's disease.
- Alzheimer's disease is marked by β-amyloid deposition, Tau hyperphosphorylation, synaptic dysfunction, and chronic neuroinflammation.
- Single-cell RNA sequencing allows for high-resolution analysis of cellular diversity in brain tissues affected by Alzheimer's.
- Pro-inflammatory microglia and reactive astrocytes have been identified as new cell subsets associated with Alzheimer's progression.
- Key molecular markers linked to disease progression have been discovered through this advanced analysis.
- Integrating single-cell RNA sequencing with AI and multi-omics may enhance understanding of the immune-inflammatory networks in Alzheimer's.
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