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Abstract
Neuron-derived SPP1 is associated with enhanced microglial activity and neuronal survival in neurodegenerative conditions.
- SPP1 reprograms microglia into a neuroprotective state after injury and during neurodegeneration.
- In mouse models, SPP1 enhances microglial functions like debris clearance and anti-inflammatory responses.
- Elevated levels of SPP1 are found in neurons of glaucomatous retinas, correlating with increased cell resilience.
- In Alzheimer's disease, neuronal SPP1 levels correlate with neuronal survival, while microglia near amyloid plaques show impaired function.
- SPP1 promotes microglial clearance of amyloid beta in human cell cultures, potentially preventing neurodegeneration.
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