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Increased neuronal activity restores circadian function in Drosophila models of C9orf72-ALS/FTD
Boosting nerve cell activity improves daily rhythm function in fruit fly models of C9orf72-linked ALS and FTD
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Abstract
Circadian rhythmicity and period length were altered in a repeat number-, dosage-, expression pattern-, and age-dependent manner.
- Circadian rhythm disruptions are observed in models of C9orf72-ALS/FTD.
- Lower levels of the neuropeptide PDF, which regulates circadian rhythms, were found.
- Decreased projection complexity and reduced neuronal activity were noted in PDF-expressing neurons.
- Increased neuronal activity could significantly rescue mild circadian dysfunction across different models and ages.
- These findings suggest a link between reduced neuronal activity and circadian deficits in C9orf72-ALS/FTD.
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