Neuronal autophagy in the control of synapse function

Mutations in autophagy genes are linked to congenital diseases with notable brain dysfunctions, including epilepsy.

• Neurons rely on autophagy to eliminate toxic proteins and organelles, which is essential for maintaining proper function.
• Disruption of core autophagy genes in neurons or glial cells results in behavioral issues such as motor deficits and memory impairment.
• Altered sociability and epilepsy have been observed in models with impaired autophagy, indicating a connection to synaptic health.
• Current understanding of the specific roles of neuronal autophagy and its impact on synaptic function in health and disease is still debated.

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