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Short Neuropeptide F Acts as a Functional Neuromodulator for Olfactory Memory in Kenyon Cells ofDrosophilaMushroom Bodies
Short neuropeptide F helps control smell memory in learning cells of fruit fly brains
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Abstract
A neuropeptide precursor gene encoding four types of short neuropeptide F (sNPF) is required in Kenyon cells for appetitive olfactory memory.
- Activation of Kenyon cells reduces sNPF levels in mushroom body lobes.
- Targeted RNA interference against the sNPF precursor significantly lowers sNPF levels in Kenyon cells.
- Knockdown of sNPF in Kenyon cells impairs sugar-rewarded olfactory memory without affecting sugar preference or odor response.
- Deficits in appetitive memory are observed with knockdown of sNPF receptors outside the mushroom bodies.
- These findings indicate that sNPF is a functional neuromodulator released by Kenyon cells.
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