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Expression of neuropeptide Y and pro‐opiomelanocortin in hypothalamic arcuate nucleus in 17α‐ethinyl estradiol‐induced intrahepatic cholestasis pregnant rat offspring
Changes in brain hunger and stress-related chemicals in offspring of pregnant rats with hormone-induced liver bile flow problems
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Abstract
Offspring of intrahepatic cholestasis pregnant rats showed lower bodyweight at birth but gained significantly more weight by 6 months.
- Expression of neuropeptide Y (NPY) was higher in intrahepatic cholestasis (ICP) offspring compared to control offspring at both birth and 6 months.
- Pro-opiomelanocortin (POMC) expression was lower in ICP offspring than in control offspring at both time points.
- Both mRNA and protein levels of NPY and POMC increased in control offspring from birth to 6 months.
- In ICP offspring, NPY expression remained elevated while POMC expression decreased over the same period.
- The findings suggest persistent appetite stimulation in ICP offspring, contributing to their weight gain.
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