Nicotinamide riboside and metformin may protect the memory area of the brain in male rats with diet-related obesity

Chronic exposure to a high-fat diet (HFD) may lead to structural alterations in the hippocampus.

• Obesity-induced metabolic disturbances could contribute to hippocampal dysfunction and neurodegeneration.
• High-fat diet exposure is associated with changes in neurotrophic and metabolic signaling.
• Increased neuronal vulnerability may result from these dietary-induced alterations.
• Cognitive performance is ultimately impaired due to these hippocampal changes.

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